Structure of PDB 4g27 Chain B Binding Site BS01

Receptor Information
>4g27 Chain B (length=87) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRKLELTKAEDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKH
QRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQLE
Ligand information
Ligand IDPHU
InChIInChI=1S/C7H8N2O/c8-7(10)9-6-4-2-1-3-5-6/h1-5H,(H3,8,9,10)
InChIKeyLUBJCRLGQSPQNN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.2c1ccc(cc1)NC(=O)N
CACTVS 3.370NC(=O)Nc1ccccc1
ACDLabs 12.01O=C(Nc1ccccc1)N
FormulaC7 H8 N2 O
Name1-phenylurea;
Phenylurea
ChEMBLCHEMBL168445
DrugBank
ZINCZINC000000391870
PDB chain4g27 Chain R Residue 1006 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4g27 Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels.
Resolution1.65 Å
Binding residue
(original residue number in PDB)		A477 L480
Binding residue
(residue number reindexed from 1)		A75 L78
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005516 calmodulin binding
GO:0015269 calcium-activated potassium channel activity
GO:0016286 small conductance calcium-activated potassium channel activity
Biological Process
GO:0006813 potassium ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4g27, PDBe:4g27, PDBj:4g27
PDBsum4g27
PubMed22929778
UniProtP70604|KCNN2_RAT Small conductance calcium-activated potassium channel protein 2 (Gene Name=Kcnn2)

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