Structure of PDB 4fxd Chain B Binding Site BS01

Receptor Information
>4fxd Chain B (length=807) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TFQMFWLDYCEVNNTLILFGKVKLKDDNCVSAMVQINGLCRELFFLPREG
KTPTDIHEEIIPLLMDKYGLDNIRAKPQKMKYSFELPDIPSESDYLKVLL
PYQTPKSSRDTIPSDLSSDTFYHVFGGNSNIFESFVIQNRIMGPCWLDIK
GADFNSIRNASHCAVEVSVDKPQNITPTTTKTMPNLRCLSLSIQTLMNPK
ENKQEIVSITLSAYRNISLDSPIPENIKPDDLCTLVRPPQSTSFPLGLAA
LAKQKLPGRVRLFNNEKAMLSCFCAMLKVEDPDVIIGHRLQNVYLDVLAH
RMHDLNIPTFSSIGRRLRRTWPEKFGRGNSNMNHFFISDICSGRLICDIA
NEMGQSLTPKCQSWDLSEMYQVTCEKEHKPLDIDYQNPQYQNDVNSMTMA
LQENITNCMISAEVSYRIQLLTLTKQLTNLAGNAWAQTLGGTRAGRNEYI
LLHEFSRNGFIVPDKVFEPEKGLHKNYVLVMDFNSLYPSIIQEFNICFTT
VDRNKEDIDELPSVPPSEVDQGVLPRLLANLVDRRREVKKVMKTETDPHK
RVQCDIRQQALKLTANSMYGCLGYVNSRFYAKPLAMLVTNKGREILMNTR
QLAESMNLLVVYGDTDSVMIDTGCDNYADAIKIGLGFKRLVNERYRLLEI
DIDNVFKKLLLHAKKKYAALTVNTTVLEVKGLDMKRREFCPLSRDVSIHV
LNTILSDKDPEEALQEVYDYLEDIRIKVETNNIRIDKYKINMKVITFVIT
KLSVAERAHALNEVMIKSNNLIPDPQYYLEKQIFAPVERLLERIDSFNVV
RLSEALG
Ligand information
Receptor-Ligand Complex Structure
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PDB4fxd Mechanism for priming DNA synthesis by yeast DNA Polymerase alpha
Resolution3.0 Å
Binding residue
(original residue number in PDB)		K1047 G1070 M1131 K1132
Binding residue
(residue number reindexed from 1)		K665 G681 M742 K743
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:1902975 mitotic DNA replication initiation

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Molecular Function
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Biological Process
External links
PDB RCSB:4fxd, PDBe:4fxd, PDBj:4fxd
PDBsum4fxd
PubMed23599895
UniProtP13382|DPOLA_YEAST DNA polymerase alpha catalytic subunit A (Gene Name=POL1)

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