Structure of PDB 4ft2 Chain B Binding Site BS01

Receptor Information

>4ft2 Chain B (length=670) Species: 4577 (Zea mays)

EPEFIGSPVAADEARSNWPKRYLKARCHYRSAKVDNVVYCLGDDVYVKAG
ENEADYIGRITEFFEGTDQCHYFTCRWFFRAEDTVINSLVSISVDGHKHD
PRRVFLSEEKNDNVLDCIISKVKIVHVDPNMDPKAKAQLIESCDLYYDMS
YSVAYSTFANTRTATLLDLYSGCGGMSTGLCLGAALSGLKLETRWAVDFN
SFACQSLKYNHPQTEVRNEKADEFLALLKEWAVLCKKYVEFVVEKLVGIC
YGGSDRENGIYFKVQWEGYGPEEDTWEPIDNLSDCPQKIREFVQEGHKRK
ILPLPGDVDVICGGPPCQKDEKNKQMVTFMDIVAYLKPKYVLMENVVDIL
KFADGYLGKYALSCLVAMKYQARLGMMVAGCYGLPQFRMRVFLWGALSSM
VLPKYPLPTYDVVVRGGAPNAFSQCMVAYDETQKPSLKKALLLGDAISDL
PKVQNHQPNDVMEYGGSPKTEFQRYIRLSRKDMLDWSFGEGAGPDEGKLL
DHQPLRLNNDDYERVQQIPVKKGANFRDLKGVRVGANNIVEWDPEIERVK
LSSGKPLVPDYAMSFIKGKSLKPFGRLWWDETVPTVVTRAEPHNQVIIHP
TQARVLTIRENARLQGFPDYYRLFGPIKEKYIQVGNAVAVPVARALGYCL
GQAYLGESEGSDPLYQLPPS

Ligand information

>4ft2 Chain P (length=7) Species: 9606 (Homo sapiens)

QTARKST

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4ft2 Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): E440 F441 V442 V443 W466 Y469 E477 N481 D484 C485
• Binding residue (residue number reindexed from 1): E240 F241 V242 V243 W266 Y269 E277 N281 D284 C285

Enzymatic activity

• Catalytic site (original residue number in PDB): C517 E559 R603 R605
• Catalytic site (residue number reindexed from 1): C317 E344 R388 R390
• Enzyme Commision number: 2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Gene Ontology

Molecular Function

• GO:0003682 chromatin binding
• GO:0008168 methyltransferase activity

External links

• PDB: RCSB:4ft2, PDBe:4ft2, PDBj:4ft2
• PDBsum: 4ft2
• PubMed: 23021223
• UniProt: Q9AXT8|CMT1_MAIZE DNA (cytosine-5)-methyltransferase 1 (Gene Name=MET2A)