Structure of PDB 4fmm Chain B Binding Site BS01

Receptor Information
>4fmm Chain B (length=325) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKNLINIDKPIKELPASIAIPKEKPLTGEQQKMYDEVLKHFSNPDLKVYT
SEKNKSEDDLKPLEEEEKAWLTRECFLRYLRATKWVLKDCIDRITMTLAW
RREFGISHLGEEHGDKITADLVAVENESGKQVILGYENDARPILYLKPGR
QNTKTSHRQVQHLVFMLERVIDFMPAGQDSLALLIDFKDYPDVPKVPPIG
VGKEVLHILQTHYPERLGKALLTNIPWLAWTFLKLIHPFIDPLTREKLVF
DEPFVKYVPKNELDSLYGGDLKFKYNHDVYWPALVETAREKRDHYFKRFQ
SFGGIVGLSEVDLRGTHEKLLYPVK
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4fmm Chain B Residue 404 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4fmm Dimeric Sfh3 has structural changes in its binding pocket that are associated with a dimer-monomer state transformation induced by substrate binding.
Resolution2.34 Å
Binding residue
(original residue number in PDB)		Y93 H232
Binding residue
(residue number reindexed from 1)		Y79 H212
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008526 phosphatidylinositol transfer activity
GO:0032934 sterol binding
GO:0042802 identical protein binding
Biological Process
GO:0006869 lipid transport
GO:0008654 phospholipid biosynthetic process
GO:0009410 response to xenobiotic stimulus
GO:0015914 phospholipid transport
GO:0016126 sterol biosynthetic process
GO:0043942 negative regulation of sexual sporulation resulting in formation of a cellular spore
GO:0120009 intermembrane lipid transfer
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0071561 nucleus-vacuole junction
GO:0071944 cell periphery
GO:1902556 phosphatidylinositol transporter complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4fmm, PDBe:4fmm, PDBj:4fmm
PDBsum4fmm
PubMed23519406
UniProtP53860|PDR16_YEAST Phosphatidylinositol transfer protein PDR16 (Gene Name=PDR16)

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