Structure of PDB 4fl0 Chain B Binding Site BS01

Receptor Information
>4fl0 Chain B (length=409) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSTKLVRNVNLEKLKNNYLFPEINRRELEHIEKHPNVQLISLGTGDTTEP
IPEQITSHMSNFAHGLSTVEGYRGYGLEQGNKTLRKAIAETFYRDLHVKS
NEVFVSDGAQSDISRLQLLLGSNVTIAVQDPTFPAYIDSSVIIGQTGHFH
EKTKKYQNVVYMPCGPNNSFFPDLAMTPRTDVIFFCSPNNPTGYVASRKQ
LHQLVDFAKTNGSIIIFDSAYAAFIEDGSPRSIYEIPGAREVAIEVSSFS
KFAGFTGVRLGWSIIPDELLYSNGFPIINDFHRIVTTSFNGASNIAQAGG
LACLSSGGLKEIRSVNNYYKENRKILMDTLVSLGLKVYGGVNAPYLWVHF
KGSKSWDVFNEILENTHIITVPGSGFGPGGEEYLRISGFGRRDHIVEASK
RLQNFFNTR
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain4fl0 Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4fl0 Structure of ALD1, a plant-specific homologue of the universal diaminopimelate aminotransferase enzyme of lysine biosynthesis.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		G141 A142 Q143 F166 N223 D251 Y254 S281 S283 K284 R292
Binding residue
(residue number reindexed from 1)		G108 A109 Q110 F133 N190 D218 Y221 S248 S250 K251 R259
Annotation score4
Enzymatic activity
Enzyme Commision number 2.6.1.-
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0062045 L-lysine alpha-aminotransferase
Biological Process
GO:0006952 defense response
GO:0009058 biosynthetic process
GO:0009627 systemic acquired resistance
GO:0009862 systemic acquired resistance, salicylic acid mediated signaling pathway
GO:0010150 leaf senescence
GO:0042742 defense response to bacterium
GO:0062034 L-pipecolic acid biosynthetic process
Cellular Component
GO:0009507 chloroplast
GO:0009536 plastid

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4fl0, PDBe:4fl0, PDBj:4fl0
PDBsum4fl0
PubMed23385743
UniProtQ9ZQI7|ALD1_ARATH Aminotransferase ALD1, chloroplastic (Gene Name=ALD1)

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