Structure of PDB 4fbw Chain B Binding Site BS01

Receptor Information

>4fbw Chain B (length=386) Species: 284812 (Schizosaccharomyces pombe 972h-)

NENTIRILISSDPHVGYGEKDPVRGNDSFVSFNEILEIARERDVDMILLG
GDIFHDNKPSRKALYQALRSLRLNCLGDKPCELELLSDAVCNINYLDPNI
NVAIPVFSIHGNHDDRYSALDILQVTGLVNYFGRVPENDNIVVSPILLQK
GFTKLALYGISNVRDERLYHSFRENKVKFLRPDLYRDEWFNLLTVHQNHS
AHTPTSYLPESFIQDFYDFVLWGHEHECLIDGSYNPTQKFTVVQPGSTIA
TSLSPGETAPKHCGILNITGKDFHLEKIRLRTVRPFIMKDIILSEVSSIP
PMVENKKEVLTYLISKVEEAITEANAQWYEAQGTVPVVENEKPPLPLIRL
RVDYTGGYQTENPQRFSNRFVGRVANATDVVQFYLK

Ligand information

>4fbw Chain C (length=21) Species: 284812 (Schizosaccharomyces pombe 972h-)

NRRLRNLGSVEYIRNFKKFQK

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4fbw Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): P119 N120 I121 N122
• Binding residue (residue number reindexed from 1): P98 N99 I100 N101

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0004519 endonuclease activity
• GO:0004520 DNA endonuclease activity
• GO:0008296 3'-5'-DNA exonuclease activity
• GO:0016787 hydrolase activity
• GO:0030145 manganese ion binding

Biological Process

• GO:0006302 double-strand break repair

Cellular Component

• GO:0005634 nucleus
• GO:0030870 Mre11 complex

External links

• PDB: RCSB:4fbw, PDBe:4fbw, PDBj:4fbw
• PDBsum: 4fbw
• PubMed: 22705791
• UniProt: Q09683|RAD32_SCHPO Double-strand break repair protein rad32 (Gene Name=rad32)