Structure of PDB 4fbe Chain B Binding Site BS01

Receptor Information

>4fbe Chain B (length=301) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ELVDIPKISYNPSELSEPRFLEYSNLSDKLHLREAIDKILIPRVVGTTNH
SIVREYIVQSLRDLDWDVEVNSFHDHAPIKGKLHFHNIIATLNPNAERYL
VLSAHYDSKYMPGVEFLGATDSAVPAAMLLNLAQVLQEQLKPLKKSKLSL
MLLFFDGEEAFEEWGPKDSIYGARHLAKKWHHEGKLDRIDMLVLLDLLGA
PDPAFYSFFENTESWYMRIQSVETRLAKLQRYFQSQAMRSSFIEDDHIPF
LRRNVPILHLIPVPFPSVWHTPDDNASVIDYATTDNLALIIRLFALEYLL
A

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

4fbe Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	4fbe Crystal Structures of Glutaminyl Cyclases (QCs) from Drosophila melanogaster Reveal Active Site Conservation between Insect and Mammalian QCs.
Resolution	1.88 Å
Binding residue (original residue number in PDB)	D153 E191 H318
Binding residue (residue number reindexed from 1)	D121 E159 H270
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.3.2.5: glutaminyl-peptide cyclotransferase.

Gene Ontology

	Molecular Function
GO:0008270	zinc ion binding
GO:0016603	glutaminyl-peptide cyclotransferase activity
GO:0016746	acyltransferase activity
GO:0046872	metal ion binding

	Cellular Component
GO:0005576	extracellular region
GO:0005739	mitochondrion

View graph for
Molecular Function

View graph for
Cellular Component

External links

PDB	RCSB:4fbe, PDBe:4fbe, PDBj:4fbe
PDBsum	4fbe
PubMed	22897232
UniProt	Q86PD7\|QPCT2_DROME Glutaminyl-peptide cyclotransferase (Gene Name=isoQC)

[Back to BioLiP]