Structure of PDB 4ezh Chain B Binding Site BS01
Receptor Information
>4ezh Chain B (length=451) Species:
10090
(Mus musculus) [
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ESYLSPAQSVKPKIEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPR
NPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDENWDL
TGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQEELEVLFHHIIKFGTN
IDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMK
VPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVD
YLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNI
AWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPD
LFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVE
VFNILFVTSTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTLA
P
Ligand information
>4ezh Chain D (length=11) Species:
32630
(synthetic construct) [
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AARKSAPATGG
Receptor-Ligand Complex Structure
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PDB
4ezh
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
Resolution
2.52 Å
Binding residue
(original residue number in PDB)
E1244 R1246 E1269 S1270 R1272 N1331 D1333 I1370 L1371 G1372 Q1377 G1435 A1482 W1483 N1484
Binding residue
(residue number reindexed from 1)
E85 R87 E110 S111 R113 N150 D152 I189 L190 G191 Q196 G254 A301 W302 N303
Enzymatic activity
Enzyme Commision number
1.14.11.68
: [histone H3]-trimethyl-L-lysine(27) demethylase.
External links
PDB
RCSB:4ezh
,
PDBe:4ezh
,
PDBj:4ezh
PDBsum
4ezh
PubMed
22842901
UniProt
Q5NCY0
|KDM6B_MOUSE Lysine-specific demethylase 6B (Gene Name=Kdm6b)
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