Structure of PDB 4eyh Chain B Binding Site BS01

Receptor Information
>4eyh Chain B (length=377) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGV
KKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGF
DENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLV
GSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELL
ASLLNRVCQDGRKPHTVRLIIRRGRESRQCPIPSHVIQKYDVMTPMVDIL
MKLFRNMVNVKMPFHLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
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PDB4eyh Replication of a carcinogenic nitropyrene DNA lesion by human Y-family DNA polymerase.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		R103 S276 P299 Q300 S301 F302 S303 E305 S307 R331 R347
Binding residue
(residue number reindexed from 1)		R78 S251 P274 Q275 S276 F277 S278 E280 S282 R306 R322
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4eyh, PDBe:4eyh, PDBj:4eyh
PDBsum4eyh
PubMed23268450
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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