Structure of PDB 4erc Chain B Binding Site BS01

Receptor Information
>4erc Chain B (length=150) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGVQPPNFSWVLPGRLAGLALPRLPAHYQFLLDLGVRHLVSLTERGPPHS
DSCPGLTLHRLRIPDFCPPAPDQIDRFVQIVDEANARGEAVGVHCALGFG
RTGTMLACYLVKERGLAAGDAIAEIRRLRPGSIETYEQEKAVFQFYQRTK
Ligand information
Ligand IDVN4
InChIInChI=1S/3O.V/q;;-1;
InChIKeyALTWGIIQPLQAAM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[O-][V](=O)=O
FormulaO3 V
Nameoxido(dioxo)vanadium
ChEMBL
DrugBank
ZINC
PDB chain4erc Chain B Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4erc New Aspects of the Phosphatase VHZ Revealed by a High-Resolution Structure with Vanadate and Substrate Screening.
Resolution1.15 Å
Binding residue
(original residue number in PDB)		C95 A96 L97 G98 F99 G100 R101
Binding residue
(residue number reindexed from 1)		C95 A96 L97 G98 F99 G100 R101
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
GO:0017018 myosin phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0060271 cilium assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4erc, PDBe:4erc, PDBj:4erc
PDBsum4erc
PubMed23145819
UniProtQ9BVJ7|DUS23_HUMAN Dual specificity protein phosphatase 23 (Gene Name=DUSP23)

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