Structure of PDB 4egc Chain B Binding Site BS01

Receptor Information
>4egc Chain B (length=255) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLAD
THLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFGGVDWMRKLAFR
YRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALN
LINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESC
FERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHAL
ELEYL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4egc Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4egc Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.
Resolution1.994 Å
Binding residue
(original residue number in PDB)		D274 D276 D502
Binding residue
(residue number reindexed from 1)		D7 D9 D219
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0007275 multicellular organism development

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Molecular Function
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Biological Process
External links
PDB RCSB:4egc, PDBe:4egc, PDBj:4egc
PDBsum4egc
PubMed23435380
UniProtO00167|EYA2_HUMAN Eyes absent homolog 2 (Gene Name=EYA2)

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