Structure of PDB 4da4 Chain B Binding Site BS01

Receptor Information

>4da4 Chain B (length=832) Species: 10090 (Mus musculus)

DRISWLGQPMKIEENRTYYQKVSIDEEMLEVGDCVSVIPDDSSKPLYLAR
VTALWEDKNGQMMFHAHWFCAGTDTVLGATSDPLELFLVGECENMQLSYI
HSKVKVIYKAPSENWAMEGGGKTYFFQLWYNQEYARFESPPKTQPTEDNK
HKFCLSCIRLAELRQKEMPKVLEQIEEVDGRVYCSSITKNGVVYRLGDSV
YLPPEAFTFNIKVASPVKRPKKDPVNETLYPEHYRKYSDYIKGSNLDAPE
PYRIGRIKEIHCGKKKGKVNEADIKLRLYKFYRPENTHRSYNGSYHTDIN
MLYWSDEEAVVNFSDVQGRCTVEYGEDLLESIQDYSQGGPDRFYFLEAYN
SKTKNFEDPPNHARSPGNIKLPKLRTLDVFSGCGGLSEGFHQAGISETLW
AIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKLVMAGEVTNSLGQRLPQKG
DVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLL
ENVRNFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAII
LAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTI
TVRDTMSDLPEIQNGASNSEIPYNGEPLSWFQRQLRGSHYQPILRDHICK
DMSPLVAARMRHIPLFPGSDWRDLPNIQVRLGDGVIAHKLQYTFHDVKNG
YSSTGALRGVCSCAEGKACDPESRQFSTLIPWCLPHTGNRHNHWAGLYGR
LEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDSYRFF
GNILDRHRQVGNAVPPPLAKAIGLEIKLCLLS

Ligand information

>4da4 Chain E (length=12)

gaggccgcctgc

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4da4 Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation.
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): G1234 N1236 R1237 R1272 S1276 R1492 C1501 H1504 R1508 H1509 W1512 M1535 G1536 K1537
• Binding residue (residue number reindexed from 1): G466 N468 R469 R504 S508 R724 C733 H736 R740 H741 W744 M767 G768 K769

Enzymatic activity

• Catalytic site (original residue number in PDB): C1229 E1269 R1313 R1315
• Catalytic site (residue number reindexed from 1): C461 E501 R545 R547
• Enzyme Commision number: 2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Gene Ontology

Molecular Function

• GO:0003682 chromatin binding
• GO:0008168 methyltransferase activity

External links

• PDB: RCSB:4da4, PDBe:4da4, PDBj:4da4
• PDBsum: 4da4
• PubMed: 22323818
• UniProt: P13864|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1 (Gene Name=Dnmt1)