Structure of PDB 4d11 Chain B Binding Site BS01

Receptor Information
>4d11 Chain B (length=482) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVRWPDFNQEAYVGGDPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKQW
RVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDP
EDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNE
HWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFK
WDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVW
GGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPGTVFARNTRRAAEVW
MDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELR
VPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECHNAGGNQEWALTKEK
SVKHMDLCLTVVDRAPGSLIKLQGCREDDSRQKWEQIEGNSKLRHVGSNL
CLDSRTAKSGGLSVEVCGPALSQQWKFTLNLQ
Ligand information
Receptor-Ligand Complex Structure
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PDB4d11 Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N- Acetylgalactosaminyltransferase 2.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		A266 W282 F361 R362 K363 H365
Binding residue
(residue number reindexed from 1)		A185 W201 F280 R281 K282 H284
Enzymatic activity
Enzyme Commision number 2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.
Gene Ontology
Molecular Function
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
GO:0030145 manganese ion binding
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0016266 O-glycan processing
GO:0018242 protein O-linked glycosylation via serine
GO:0018243 protein O-linked glycosylation via threonine
GO:0051604 protein maturation
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0016020 membrane
GO:0032580 Golgi cisterna membrane
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4d11, PDBe:4d11, PDBj:4d11
PDBsum4d11
PubMed24954443
UniProtQ10471|GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 (Gene Name=GALNT2)

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