Structure of PDB 4ct7 Chain B Binding Site BS01

Receptor Information
>4ct7 Chain B (length=269) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QVDREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAA
LLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHI
PLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIP
LCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGK
MVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQV
LKDDTTTKRWLAQLVKNLQ
Ligand information
Ligand IDTRP
InChIInChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1
InChIKeyQIVBCDIJIAJPQS-VIFPVBQESA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(N)Cc2c1ccccc1nc2
OpenEye OEToolkits 1.5.0c1ccc2c(c1)c(c[nH]2)C[C@@H](C(=O)O)N
OpenEye OEToolkits 1.5.0c1ccc2c(c1)c(c[nH]2)CC(C(=O)O)N
CACTVS 3.341N[CH](Cc1c[nH]c2ccccc12)C(O)=O
CACTVS 3.341N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
FormulaC11 H12 N2 O2
NameTRYPTOPHAN
ChEMBLCHEMBL54976
DrugBankDB00150
ZINCZINC000000083315
PDB chain4ct7 Chain B Residue 1286 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4ct7 Structural and Biochemical Insights to the Role of the Ccr4-not Complex and Ddx6 ATPase in Microrna Repression.
Resolution1.897 Å
Binding residue
(original residue number in PDB)		C200 T202 Y203 F206 R244
Binding residue
(residue number reindexed from 1)		C185 T187 Y188 F191 R229
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0019904 protein domain specific binding
GO:0030374 nuclear receptor coactivator activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006402 mRNA catabolic process
GO:0006417 regulation of translation
GO:0007548 sex differentiation
GO:0017148 negative regulation of translation
GO:0019221 cytokine-mediated signaling pathway
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0030014 CCR4-NOT complex
GO:0030015 CCR4-NOT core complex
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ct7, PDBe:4ct7, PDBj:4ct7
PDBsum4ct7
PubMed24768538
UniProtQ92600|CNOT9_HUMAN CCR4-NOT transcription complex subunit 9 (Gene Name=CNOT9)

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