Structure of PDB 4cn5 Chain B Binding Site BS01

Receptor Information

>4cn5 Chain B (length=75) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCKDCLIDKRQR
NRCQYCRYQKCLAMGMKREAVQEER

Ligand information

>4cn5 Chain C (length=17) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tggggtcagagttcaat

Receptor-Ligand Complex Structure

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PDB	4cn5 Structural Basis of Natural Promoter Recognition by the Retinoid X Nuclear Receptor.
Resolution	2.0 Å
Binding residue (original residue number in PDB)	K145 H146 Y147 K156 R164 Q206 E208 R209
Binding residue (residue number reindexed from 1)	K14 H15 Y16 K25 R33 Q72 E74 R75
Binding affinity	PDBbind-CN: Kd=40nM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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External links

PDB	RCSB:4cn5, PDBe:4cn5, PDBj:4cn5
PDBsum	4cn5
PubMed	25645674
UniProt	P19793\|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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