Structure of PDB 4ci2 Chain B Binding Site BS01

Receptor Information
>4ci2 Chain B (length=370) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MINFDTSLPTSHMYLGSDMEEFHGRTLHDDDSCQVIPVLPHVMVMLIPGQ
TLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVREREAHFGTTAEIYAYR
EEQEYGIETVKVKAIGRQRFKVLEIRTQSDGIQQAKVQILPERVLPSTMS
AVQLQSLSRRHIRAFRQWWQKYQKRKFHCASLTSWPPWLYSLYDAETLME
RVKRQLHEWDENLKDESLPTNPIDFSYRVAACLPIDDALRIQLLKIGSAI
QRLRCELDIMNKCTSLCCKQCQDTEITTKNEIFSLSLCGPMAAYVNPHGY
IHETLTVYKACNLNLSGRPSTEHSWFPGYAWTIAQCRICGNHMGWKFTAT
KKDMSPQKFWGLTRSALLPR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4ci2 Chain B Residue 1428 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4ci2 Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		C325 C328 C393 C396
Binding residue
(residue number reindexed from 1)		C268 C271 C336 C339
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ci2, PDBe:4ci2, PDBj:4ci2
PDBsum4ci2
PubMed25043012
UniProtP0CF65|CRBN_CHICK Protein cereblon (Gene Name=CRBN)

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