Structure of PDB 4ccm Chain B Binding Site BS01
Receptor Information
>4ccm Chain B (length=459) Species:
9606
(Homo sapiens) [
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MSPLRRVLAELNRIPSSRRRAARLFEWLIAPMPPDHFYRRLWEREAVLVR
RQDHTYYQGLFSTADLDSMLRNEEVQFGQHLDAARYINGRRETLNPPGRA
LPAAAWSLYQAGCSLRLLCPQAFSTTVWQFLAVLQEQFGSMAGSNVYLTP
PNSQGFAPHYDDIEAFVLQLEGRKLWRVYRPRVPTEELALTSSPNFSQDD
LGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTLSTYQRNTWGDF
LEAILPLAVQAAMEENVEFRRGLPRDFMDYMGAQHSDSKDPRRTAFMEKV
RVLVARLGHFAPVDAVADQRAKDFIHDSLPPVLTDRERALSVYGLPIRWE
AGEPVNVGAQLTTETEVHMLQDGIARLVGEGGHLFLYYTVENSRVYHLEE
PKCLEIYPQQADAMELLLGSYPEFVRVGDLPCDSVEDQLSLATTLYDKGL
LLTKMPLAL
Ligand information
>4ccm Chain D (length=11) Species:
9606
(Homo sapiens) [
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GGGNHQHICKP
Receptor-Ligand Complex Structure
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PDB
4ccm
Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Resolution
2.51 Å
Binding residue
(original residue number in PDB)
Q260 R272 T274 R297 L299 C300 M322 N326 Y328 H340 D342 N376 S421 Q424 Y577
Binding residue
(residue number reindexed from 1)
Q79 R91 T93 R116 L118 C119 M141 N145 Y147 H159 D161 N195 S240 Q243 Y396
Enzymatic activity
Enzyme Commision number
1.14.11.27
: [histone H3]-dimethyl-L-lysine(36) demethylase.
1.14.11.79
: protein-L-histidine (3S)-3-hydroxylase.
External links
PDB
RCSB:4ccm
,
PDBe:4ccm
,
PDBj:4ccm
PDBsum
4ccm
PubMed
24814345
UniProt
Q9H6W3
|RIOX1_HUMAN Ribosomal oxygenase 1 (Gene Name=RIOX1)
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