Structure of PDB 4c1l Chain B Binding Site BS01

Receptor Information

>4c1l Chain B (length=262) Species: 2261 (Pyrococcus furiosus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MKYSKEYKEKTVVKINDVKFGEGFTIIAGPCSIESRDQIMKVAEFLAEVG
IKVLRGGAFKPRTSPYSFQGYGEKALRWMREAADEYGLVTVTEVMDTRHV
ELVAKYSDILQIGARNSQNFELLKEVGKVENPVLLKRGMGNTIQELLYSA
EYIMAQGNENVILCERGIRTFETATRFTLDDSAVPVVKELSHLPIIVDPS
HPAGRRSLVIPLAKAAYAIGADGIMVEVHPEPEKALSDSQQQLTFDDFLQ
LLKELEALGWKG

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

4c1l Chain B Residue 1263 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4c1l Destabilization of the homotetrameric assembly of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from the hyperthermophile Pyrococcus furiosus enhances enzymatic activity.
Resolution	1.8 Å
Binding residue (original residue number in PDB)	C31 H201 E227 D238
Binding residue (residue number reindexed from 1)	C31 H201 E227 D238
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.

Gene Ontology

	Molecular Function
GO:0003849	3-deoxy-7-phosphoheptulonate synthase activity
GO:0016740	transferase activity
GO:0016832	aldehyde-lyase activity
GO:0046872	metal ion binding

	Biological Process
GO:0009058	biosynthetic process
GO:0009073	aromatic amino acid family biosynthetic process

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Molecular Function

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Biological Process

External links

PDB	RCSB:4c1l, PDBe:4c1l, PDBj:4c1l
PDBsum	4c1l
PubMed	24239948
UniProt	Q8U0A9

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