Structure of PDB 4bxf Chain B Binding Site BS01

Receptor Information
>4bxf Chain B (length=422) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SALNFDSPSSLFESLISPIKTETFFKEFWEQKPLLIQRDDPALATYYGSL
FKLTDLKSLCSRGMYYGRDVNVCRCVNGKKKVLNKDGKAHFLQLRKDFDQ
KRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGSQGLPPHY
DDVEVFILQLEGEKHWRLYHPTVPLARECSVEAEERIGRPVHEFMLKPGD
LLYFPRGTIHQADTPAGLAHSTHVTISTYQNNSWGDFLLDTISGLVFDTA
KEDVELRTGIPRQLLLQVESTTVATRRLSGFLRTLADRLEGTKELLSSDM
KKDFIMHRLPPYSAGDGAELSTPGGKLPRLDSVVRLQFKDHIVLTVLPQE
KMVYIYHSLKNSRETHMMTEFHGLRFPLSHLDALKQIWNSPAISVKDLKL
TTDEEKESLVLSLWTECLIQVV
Ligand information
Receptor-Ligand Complex Structure
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PDB4bxf Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		Q136 H138 Q139 L161 N165 Y167 H179 D181 C209 T255 S257 Q260 D333 H337 M405 M406
Binding residue
(residue number reindexed from 1)		Q106 H108 Q109 L131 N135 Y137 H149 D151 C179 T225 S227 Q230 D303 H307 M367 M368
Enzymatic activity
Enzyme Commision number 1.14.11.79: protein-L-histidine (3S)-3-hydroxylase.
Gene Ontology
Molecular Function
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0032452 histone demethylase activity
GO:0032453 histone H3K4 demethylase activity
GO:0036139 peptidyl-histidine dioxygenase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0051864 histone H3K36 demethylase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0042254 ribosome biogenesis
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4bxf, PDBe:4bxf, PDBj:4bxf
PDBsum4bxf
PubMed24814345
UniProtQ8IUF8|RIOX2_HUMAN Ribosomal oxygenase 2 (Gene Name=RIOX2)

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