Structure of PDB 4bwe Chain B Binding Site BS01

Receptor Information
>4bwe Chain B (length=422) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENL
ANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFP
GAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQ
LHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGL
GVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLK
GCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINA
LQDNRDTLTAKVIQGCGNPKVNPSGTLEKLVSEAKAQLRDVQDFWISLPG
TLCSEKMADRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIR
QQIMQLKIMTNRLRSAYNGNDV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4bwe Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4bwe Improvements in the order, isotropy and electron density of glypican-1 crystals by controlled dehydration.
Resolution2.46 Å
Binding residue
(original residue number in PDB)		I437 E443
Binding residue
(residue number reindexed from 1)		I383 E389
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0009966 regulation of signal transduction
Cellular Component
GO:0005886 plasma membrane
GO:0062023 collagen-containing extracellular matrix

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Biological Process
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Cellular Component
External links
PDB RCSB:4bwe, PDBe:4bwe, PDBj:4bwe
PDBsum4bwe
PubMed24311593
UniProtP35052|GPC1_HUMAN Glypican-1 (Gene Name=GPC1)

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