Structure of PDB 4bw5 Chain B Binding Site BS01

Receptor Information
>4bw5 Chain B (length=254) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHV
CVSPQELETLIQHALDADNAGVSPIGSHWDLGSAFFFAGTVITTIGYGNI
APSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRK
KQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVT
LTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLR
VLSK
Ligand information
Ligand IDK
InChIInChI=1S/K/q+1
InChIKeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[K+]
FormulaK
NamePOTASSIUM ION
ChEMBLCHEMBL1233793
DrugBankDB01345
ZINC
PDB chain4bw5 Chain A Residue 600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4bw5 K2P Channel Gating Mechanisms Revealed by Structures of Trek-2 and a Complex with Prozac
Resolution3.2 Å
Binding residue
(original residue number in PDB)		G174 Y175 G176 G283 F284 G285
Binding residue
(residue number reindexed from 1)		G96 Y97 G98 G205 F206 G207
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
Biological Process
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4bw5, PDBe:4bw5, PDBj:4bw5
PDBsum4bw5
PubMed25766236
UniProtP57789|KCNKA_HUMAN Potassium channel subfamily K member 10 (Gene Name=KCNK10)

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