Structure of PDB 4bv0 Chain B Binding Site BS01

Receptor Information

>4bv0 Chain B (length=302) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNGVTLFTLARLQSRVDYYL
GSLALSDLLILLFALPVDVYNFIWVHHPWAFGDAGCKGYYFLREACTYAT
ALNVVSLSVELYLAIRHPFKHKTMSRSRTKKFISAIWLASALLAIPMLFT
VGLQNLSGDGTHPGGLVCTPIVDTATLKVVIQLNTFMSFLFPMLVASILN
TVIARRLTVMVRVQALRRGVLVLRAMVIAFVVCWLPYHVRRLMFVYISDE
QWTTALFDFYHYFYMLSNALVYVSAAINPILYNLVSANFRQVFLSTLACL
CP

Ligand information

>4bv0 Chain D (length=7) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GRRPYIL

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4bv0 Structure of Signaling-Competent Neurotensin Receptor 1 Obtained by Directed Evolution in Escherichia Coli
Resolution	3.1 Å
Binding residue (original residue number in PDB)	D54 L55 F128 H132 Y146 V224 T226 P227 R327 F331 I334 S335 D336 W339 F344 Y347
Binding residue (residue number reindexed from 1)	D4 L5 F72 H76 Y90 V167 T169 P170 R240 F244 I247 S248 D249 W252 F257 Y260

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity
GO:0016492	G protein-coupled neurotensin receptor activity

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway

	Cellular Component
GO:0016020	membrane

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Cellular Component

External links

PDB	RCSB:4bv0, PDBe:4bv0, PDBj:4bv0
PDBsum	4bv0
PubMed	24453215
UniProt	P20789\|NTR1_RAT Neurotensin receptor type 1 (Gene Name=Ntsr1)

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