Structure of PDB 4bdq Chain B Binding Site BS01

Receptor Information
>4bdq Chain B (length=249) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIR
LVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSK
PFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKIST
YDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCN
LTQIGGLIDSKGYGVGTPMGSPYADKITIAILQLQEEGKLHMMKEKWWC
Ligand information
Ligand IDGLU
InChIInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKeyWHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.0C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.0C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370N[CH](CCC(O)=O)C(O)=O
FormulaC5 H9 N O4
NameGLUTAMIC ACID
ChEMBLCHEMBL575060
DrugBankDB00142
ZINCZINC000001482113
PDB chain4bdq Chain B Residue 900 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4bdq Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		Y488 A518 R523 G688 A689 T690 E738
Binding residue
(residue number reindexed from 1)		Y57 A87 R92 G137 A138 T139 E187
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4bdq, PDBe:4bdq, PDBj:4bdq
PDBsum4bdq
PubMed23720540
UniProtP42260|GRIK2_RAT Glutamate receptor ionotropic, kainate 2 (Gene Name=Grik2)

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