Structure of PDB 4b3o Chain B Binding Site BS01

Receptor Information
>4b3o Chain B (length=410) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPY
NTPVFAIKKKDGTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSV
TVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGS
PAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELR
QHLLRWGLTGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIY
PGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDP
SKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEA
VQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWVPEWEFVNTPP
LVKLWYQLEK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4b3o Complexes of HIV-1 RT, Nnrti and RNA/DNA Hybrid Reveal a Structure Compatible with RNA Degradation
Resolution3.3 Å
Binding residue
(original residue number in PDB)		Q394 K395 F416 N418
Binding residue
(residue number reindexed from 1)		Q373 K374 F395 N397
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0003964 RNA-directed DNA polymerase activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4b3o, PDBe:4b3o, PDBj:4b3o
PDBsum4b3o
PubMed23314251
UniProtP04585|POL_HV1H2 Gag-Pol polyprotein (Gene Name=gag-pol)

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