Structure of PDB 4ayy Chain B Binding Site BS01

Receptor Information
>4ayy Chain B (length=257) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF
Ligand information
Receptor-Ligand Complex Structure
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PDB4ayy Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		F19 K21 R68 T69 R70 Y71
Binding residue
(residue number reindexed from 1)		F19 K21 R68 T69 R70 Y71
Enzymatic activity
Catalytic site (original residue number in PDB) H43 D99 E202 G203 D204 S205 G206
Catalytic site (residue number reindexed from 1) H43 D99 E202 G203 D204 S205 G206
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:4ayy, PDBe:4ayy, PDBj:4ayy
PDBsum4ayy
PubMed7966150
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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