Structure of PDB 4au2 Chain B Binding Site BS01

Receptor Information

>4au2 Chain B (length=354) Species: 9615 (Canis lupus familiaris) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LSPKAATLAERSAGLAFSLYQAMAKDQAVENILLSPVVVASSLGLVSLGG
KATTASQAKAVLSAEQLRDEEVHAGLGELLRTWKLGSRLYGPSSVSFAED
FVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERT
DGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNY
YDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMG
KMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGLYL
ASVFHATAFEWDTEGNPELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLV
RPKG

Ligand information

>4au2 Chain E (length=14) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

PPGPPGPRGPPGPP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4au2 Molecular Basis for the Action of the Collagen-Specific Chaperone Hsp47/Serpinh1 and its Structure-Specific Client Recognition.
Resolution	2.3 Å
Binding residue (original residue number in PDB)	R228 H274 L381 Y383
Binding residue (residue number reindexed from 1)	R183 H229 L324 Y326

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005518	collagen binding

	Cellular Component
GO:0005581	collagen trimer
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum

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Molecular Function

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Cellular Component

External links

PDB	RCSB:4au2, PDBe:4au2, PDBj:4au2
PDBsum	4au2
PubMed	22847422
UniProt	C7C419

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