Structure of PDB 4afj Chain B Binding Site BS01

Receptor Information
>4afj Chain B (length=347) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVA
IKKVLQKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPE
TVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNL
LLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN
YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH
SFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI
Ligand information
>4afj Chain Y (length=23) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
HRLLQQLVLSGNLIKEAVRRLHS
Receptor-Ligand Complex Structure
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PDB4afj 5-Aryl-4-Carboxamide-1,3-Oxazoles: Potent and Selective Gsk-3 Inhibitors.
Resolution1.98 Å
Binding residue
(original residue number in PDB)		I228 F229 V263 L266 V267 I270 T275 Y288 E290 F291 K292 F293 P294 I296
Binding residue
(residue number reindexed from 1)		I191 F192 V226 L229 V230 I233 T238 Y251 E253 F254 K255 F256 P257 I259
Enzymatic activity
Catalytic site (original residue number in PDB) D181 K183 N186 D200 S219
Catalytic site (residue number reindexed from 1) D144 K146 N149 D163 S182
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4afj, PDBe:4afj, PDBj:4afj
PDBsum4afj
PubMed22310227
UniProtP49841|GSK3B_HUMAN Glycogen synthase kinase-3 beta (Gene Name=GSK3B)

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