Structure of PDB 4a5w Chain B Binding Site BS01

Receptor Information
>4a5w Chain B (length=871) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETR
ECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPL
VAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDER
DCGRTKAVCTRKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTV
KSSRTSNPYRVPANLENVGFEVQTAEDDLKTDFYKDLTSLQGGSSFSVPI
FYSSKRSENINHNSAFKQAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLH
LSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSS
EELKNSGLTEEEAKHCVRIETHRCTTNKLSEKHEGSFIQGAEKSISLIRG
GEEKTFSEWLESVKENPAVIDFELAPIVDLVRNIPCAVTKRNNLRKALQE
YAAKFDPCQCAPCPNNGRPTLSGTECLCVCQSGTYGENCEKQSPDYKSNA
VDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCTF
SIMENNGQPCINDDEEMKEVDLPEIEADSGCPQPVPPENGFIRNEKQLYL
VGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVL
TITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPPISNSLTCEK
DTLTKLKGHCQLGQKQSGSECICMSPEEDCSHHSEDLCVFDTDSNDYFTS
PACKFLAEKCLNNQQLHFLHIGSCQDGRQLEWGLERTRLSSNSTKKESCG
YDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKMGSSTSEKTLNICE
VGTIRCANRKMEILHPGKCLA
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4a5w Chain B Residue 1000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4a5w Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		L156 N159 N162 D172
Binding residue
(residue number reindexed from 1)		L135 N138 N141 D151
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006955 immune response
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0031640 killing of cells of another organism
GO:0045087 innate immune response
GO:0050778 positive regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4a5w, PDBe:4a5w, PDBj:4a5w
PDBsum4a5w
PubMed22832194
UniProtP13671|CO6_HUMAN Complement component C6 (Gene Name=C6)

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