Structure of PDB 4a08 Chain B Binding Site BS01

Receptor Information

>4a08 Chain B (length=353) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TSILHYIYKSSLGQSIHAQLRQCLQEPFIRSLKSYKLHRTASPFDRRVTS
LEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFNQ
FNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQML
ATGDSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDAT
VKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRVY
SSYDWSKPDQIIIHPHRQFQHLTPIKATWHPMYDLIVAGRYPDDQLLLND
KRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTGDVLASGMGFNILIW
NRE

Ligand information

>4a08 Chain G (length=10) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cgcgatgcgc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4a08 The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation
Resolution	3.0 Å
Binding residue (original residue number in PDB)	R148 K168 W239 K280 P326 Q345 Q372 H373
Binding residue (residue number reindexed from 1)	R46 K66 W137 K178 P224 Q243 Q270 H271

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding

	Biological Process
GO:0006281	DNA repair

	Cellular Component
GO:0005634	nucleus
GO:0080008	Cul4-RING E3 ubiquitin ligase complex

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Cellular Component

External links

PDB	RCSB:4a08, PDBe:4a08, PDBj:4a08
PDBsum	4a08
PubMed	22118460
UniProt	Q2YDS1\|DDB2_DANRE DNA damage-binding protein 2 (Gene Name=ddb2)

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