Structure of PDB 3wpc Chain B Binding Site BS01

Receptor Information
>3wpc Chain B (length=749) Species: 9796 (Equus caballus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLPPFLPCELQPHGLVNCNWLFLKSVPHFSAAAPRDNVTSLSLLSNRIHH
LHDSDFAQLSNLQKLNLKWNCPPAGLSPMHFPCHMTIEPNTFLAVPTLEE
LNLSYNGITTVPALPSSLVSLILSRTNILQLDPTSLTGLHALRFLYMDGN
CYYKNPCGRALEVAPGALLGLGNLTHLSLKYNNLTTVPRSLPPSLEYLLL
SYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCVECPHKFPQLHS
DTFSHLSRLEGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENFLYDCITKT
KAFQGLAQLRRLNLSFNYHKKVSFAHLTLAPSFGSLLSLQELDMHGIFFR
SLSQKTLQPLARLPMLQRLYLQMNFINQAQLGIFKDFPGLRYIDLSDNRI
SGAVESEDFMPSCKNLSFTLDLSRNNLVTVQPEMFAQLSRLQCLRLSHNS
ISQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTELPRLEALDLSYNSQ
PFSMRGVGHNLSFVAQLPTLRYLSLAHNGIHSRVSQQLCSTSLWALDFSG
NSLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRLHTLLPCTLGNLPKSLQL
LRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLD
VSRNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDV
SANPLHCACGAAFVDFLLQVQAAVPGLPSRVKCGSPGQLQGRSIFAQDL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3wpc Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Resolution1.6 Å
Binding residue
(original residue number in PDB)		W47 F49 K51 S72 R74 H77 W96 S104 P105 M106 F108 Y132 R152 Y179 Y180 K181 Y208 R262 N263
Binding residue
(residue number reindexed from 1)		W20 F22 K24 S45 R47 H50 W69 S77 P78 M79 F81 Y105 R125 Y152 Y153 K154 Y181 R235 N236
Binding affinityPDBbind-CN: Kd=20nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3wpc, PDBe:3wpc, PDBj:3wpc
PDBsum3wpc
PubMed25686612
UniProtQ2EEY0|TLR9_HORSE Toll-like receptor 9 (Gene Name=TLR9)

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