Structure of PDB 3wne Chain B Binding Site BS01

Receptor Information
>3wne Chain B (length=132) Species: 11698 (Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAG
RWPVKTVHTDNGSNFTGATVRAACDWAGIKQEMNKELKKIIGQVRDQAEH
LKTAVQMAVFIHNHKRGYSAGERIVDIIATDI
Ligand information
Receptor-Ligand Complex Structure
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PDB3wne Hexapeptide mimetics of LEDGF in complex with HIV-1 integrase
Resolution1.7 Å
Binding residue
(original residue number in PDB)		D167 Q168 A169 E170 H171 T174
Binding residue
(residue number reindexed from 1)		D96 Q97 A98 E99 H100 T103
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:3wne, PDBe:3wne, PDBj:3wne
PDBsum3wne
PubMed
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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