Structure of PDB 3wa0 Chain B Binding Site BS01

Receptor Information
>3wa0 Chain B (length=290) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTV
AWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQV
KKQILDEKVYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKR
VINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYF
TIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFT
IKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRK
Ligand information
Receptor-Ligand Complex Structure
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PDB3wa0 Structural basis of DDB1-and-Cullin 4-associated Factor 1 (DCAF1) recognition by merlin/NF2 and its implication in tumorigenesis by CD44-mediated inhibition of merlin suppression of DCAF1 function.
Resolution2.31 Å
Binding residue
(original residue number in PDB)		K76 D78
Binding residue
(residue number reindexed from 1)		K54 D56
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0008092 cytoskeletal protein binding
Cellular Component
GO:0005856 cytoskeleton

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Molecular Function
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Cellular Component
External links
PDB RCSB:3wa0, PDBe:3wa0, PDBj:3wa0
PDBsum3wa0
PubMed24912773
UniProtP46662|MERL_MOUSE Merlin (Gene Name=Nf2)

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