Structure of PDB 3ukz Chain B Binding Site BS01

Receptor Information
>3ukz Chain B (length=427) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISL
LASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLST
LACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLAD
SCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNI
VTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQI
QQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCG
IIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGL
DKIEALQRHENESVYKASLNLIEKYFS
Ligand information
>3ukz Chain C (length=23) Species: 10090 (Mus musculus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MSRRRHSYENDGGQPHKRRKTSD
Receptor-Ligand Complex Structure
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PDB3ukz Structural Basis of High-Affinity Nuclear Localization Signal Interactions with Importin-alpha
Resolution2.3 Å
Binding residue
(original residue number in PDB)		L104 S105 R106 P110 W142 N146 S149 G150 T155 Q181 W184 N188 G191 D192 N228 W231 R238 W273 Y277 G281 N283 R315 N319 T322 E354 W357 N361 E396 W399
Binding residue
(residue number reindexed from 1)		L34 S35 R36 P40 W72 N76 S79 G80 T85 Q111 W114 N118 G121 D122 N158 W161 R168 W203 Y207 G211 N213 R245 N249 T252 E284 W287 N291 E326 W329
Enzymatic activity
Catalytic site (original residue number in PDB) T151 A163 N361 R366 Q367
Catalytic site (residue number reindexed from 1) T81 A93 N291 R296 Q297
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ukz, PDBe:3ukz, PDBj:3ukz
PDBsum3ukz
PubMed22248489
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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