Structure of PDB 3u7h Chain B Binding Site BS01

Receptor Information
>3u7h Chain B (length=375) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSLGWESLKKLLVFTASGVKPQGKVAAFALDGTLITTRSGKVFPTSPSDW
RILYPEIPKKLQELAAEGYKLVIFTNQMGIGRGKLPAEVFKGKVEAVLEK
LGVPFQVLVATHAGLNRKPVSGMWDHLQEQANEGIPISVEDSVFVGDAAG
RLANWAPGRKKKDFSCADRLFALNVGLPFATPEEFFLKWPAARFELPAFD
PRTISSAGPLYLPESSSLLSPNPEVVVAVGFPGAGKSTFIQEHLVSAGYV
HVNRDTLCVSSCQAALRQGKRVVIDNTNPDVPSRARYIQCAKDAGVPCRC
FNFCATIEQARHNNRFREMTDPSHAPVSDMVMFSYRKQFEPPTLAEGFLE
ILEIPFRLQHLDPALQRLYRQFSEG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3u7h Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		D172 N217 Q218 M219 R258 F305
Binding residue
(residue number reindexed from 1)		D31 N76 Q77 M78 R117 F164
Enzymatic activity
Enzyme Commision number 2.7.1.78: polynucleotide 5'-hydroxyl-kinase.
3.1.3.32: polynucleotide 3'-phosphatase.
Gene Ontology
Molecular Function
GO:0046403 polynucleotide 3'-phosphatase activity
GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3u7h, PDBe:3u7h, PDBj:3u7h
PDBsum3u7h
PubMed22171004
UniProtQ9JLV6|PNKP_MOUSE Bifunctional polynucleotide phosphatase/kinase (Gene Name=Pnkp)

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