Structure of PDB 3u51 Chain B Binding Site BS01

Receptor Information
>3u51 Chain B (length=255) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQE
AQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRL
PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGPIKW
TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG
YRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQ
PGENL
Ligand information
Receptor-Ligand Complex Structure
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PDB3u51 Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles.
Resolution2.241 Å
Binding residue
(original residue number in PDB)		G274 G276 F278 V281 A293 M341 R388 A390 L393
Binding residue
(residue number reindexed from 1)		G14 G16 F18 V21 A33 M81 R128 A130 L133
Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404
Catalytic site (residue number reindexed from 1) D126 R128 A130 N131 D144
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3u51, PDBe:3u51, PDBj:3u51
PDBsum3u51
PubMed22344177
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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