Structure of PDB 3u4s Chain B Binding Site BS01
Receptor Information
>3u4s Chain B (length=349) Species:
9606
(Homo sapiens) [
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ETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKP
RASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDK
YCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRT
ILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEP
KSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGI
PFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVL
CSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL
Ligand information
>3u4s Chain D (length=6) Species:
9606
(Homo sapiens) [
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ARKSCG
Receptor-Ligand Complex Structure
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PDB
3u4s
Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases.
Resolution
2.15 Å
Binding residue
(original residue number in PDB)
N86 D135 E169 G170 Y175 Y177 K241 S288 N290 D311 V313
Binding residue
(residue number reindexed from 1)
N81 D130 E164 G165 Y170 Y172 K236 S283 N285 D306 V308
Enzymatic activity
Catalytic site (original residue number in PDB)
G170 Y177 H188 E190 H276 S288
Catalytic site (residue number reindexed from 1)
G165 Y172 H183 E185 H271 S283
Enzyme Commision number
1.14.11.66
: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69
: [histone H3]-trimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:3u4s
,
PDBe:3u4s
,
PDBj:3u4s
PDBsum
3u4s
PubMed
22241642
UniProt
O75164
|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)
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