Structure of PDB 3twv Chain B Binding Site BS01
Receptor Information
>3twv Chain B (length=157) Species:
9606
(Homo sapiens) [
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GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYN
RVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV
ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDT
DIQDLLR
Ligand information
>3twv Chain E (length=12) Species:
9606
(Homo sapiens) [
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QRTQPDGQSFRS
Receptor-Ligand Complex Structure
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PDB
3twv
Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
Resolution
2.301 Å
Binding residue
(original residue number in PDB)
K557 W591 K621 R623 D624 G625
Binding residue
(residue number reindexed from 1)
K70 W104 K134 R136 D137 G138
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:3twv
,
PDBe:3twv
,
PDBj:3twv
PDBsum
3twv
PubMed
22153077
UniProt
Q9H2K2
|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)
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