Structure of PDB 3twt Chain B Binding Site BS01
Receptor Information
>3twt Chain B (length=155) Species:
9606
(Homo sapiens) [
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GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIRQSTPLHFAAGYNRV
SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVAD
LWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDI
QDLLR
Ligand information
>3twt Chain E (length=12) Species:
9606
(Homo sapiens) [
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QRPPPIGQSFRS
Receptor-Ligand Complex Structure
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PDB
3twt
Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
Resolution
1.85 Å
Binding residue
(original residue number in PDB)
L590 W591 K592 K621 R623 D624
Binding residue
(residue number reindexed from 1)
L101 W102 K103 K132 R134 D135
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:3twt
,
PDBe:3twt
,
PDBj:3twt
PDBsum
3twt
PubMed
22153077
UniProt
Q9H2K2
|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)
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