Structure of PDB 3twr Chain B Binding Site BS01
Receptor Information
>3twr Chain B (length=157) Species:
9606
(Homo sapiens) [
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GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYN
RVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV
ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDT
DIQDLLR
Ligand information
>3twr Chain E (length=13) Species:
9606
(Homo sapiens) [
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LQRSPPDGQSFRS
Receptor-Ligand Complex Structure
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PDB
3twr
Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
Resolution
1.55 Å
Binding residue
(original residue number in PDB)
L590 W591 K621 R623 D624
Binding residue
(residue number reindexed from 1)
L103 W104 K134 R136 D137
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:3twr
,
PDBe:3twr
,
PDBj:3twr
PDBsum
3twr
PubMed
22153077
UniProt
Q9H2K2
|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)
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