Structure of PDB 3thz Chain B Binding Site BS01

Receptor Information
>3thz Chain B (length=846) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKSIYTPLELQYIEMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYC
HLDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETAALKAIGDNRSS
LFSRKLTALYTKSTLIGEDVNPTDTSTSYLLCISENKKKKGNIFIGIVGV
QPATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSALSEQTEALIHRA
TSVSVQDDRIRVERMDNIYFEYSHAFQAVTEFYAKGIVNLEKPVICSLAA
IIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGTTLRNLEILQNQTDMK
TKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEVLHSES
SVFGQIENHLRKLPDIERGLCSIYHKKCSTQEFFLIVKTLYHLKSEFQAI
IPAVNSHIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKVGDKTELFKD
LSDFPLIKKRKDEIQGVIDEIRMHLQEIRKILKNPSAQYVTVSGQEFMIE
IKNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHLNQLREQLVLDCSA
EWLDFLEKFSEHYHSLCKAVHHLATVDCIFSLAKVAKQGDYCRPTVQEER
KIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMGGKSSY
IKQVALITIMAQIGSYVPAEEATIGIVDGIFTRMGAAGRSTFMEELTDTA
EIIRKATSQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTH
YPPVCELEKNYSHQVGNYHMGFLVFVTFLYQITRGIAARSYGLNVAKLAD
VPGEILKKAAHKSKELEGLINTKRKRLKYFAKLWTMHNAQDLQKWT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3thz Mechanism of mismatch repair revealed by human MutS bound to unpaired DNA loops
Resolution4.3 Å
Binding residue
(original residue number in PDB)		S216 T221 L223 C243 G244 Y245 L316 F317 S750
Binding residue
(residue number reindexed from 1)		S1 T6 L8 C28 G29 Y30 L101 F102 S504
Binding affinityPDBbind-CN: Kd=0.1nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006298 mismatch repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3thz, PDBe:3thz, PDBj:3thz
PDBsum3thz
PubMed22179786
UniProtP20585|MSH3_HUMAN DNA mismatch repair protein Msh3 (Gene Name=MSH3)

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