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Receptor Information

>3thx Chain B (length=852) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KSIYTPLELQYIEMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYCH
LDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETAALKAIGDNRSSL
FSRKLTALYTKSTLIGEDVNPLIKLAVNVDEIMTDTSTSYLLCISENKNI
FIGIVGVQPATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSALSEQT
EALIHRATSVSVQDDRIRVERMDNIYFEYSHAFQAVTEFYAIVNLEKPVI
CSLAAIIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGTTLRNLEILQN
QTDMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEV
LHSESSVFGQIENHLRKLPDIERGLCSIYHKKCSTQEFFLIVKTLYHLKS
EFQAIIPAVNSHIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKVGDKT
ELFKDLSDFPLIKKRKDEIQGVIDEIRMHLQEIRKILKNPSAQYVTVSGQ
EFMIEIKNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHLNQLREQLV
LDCSAEWLDFLEKFSEHYHSLCKAVHHLATVDCIFSLAKVAKQGDYCRPT
VQEERKIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMG
GKSSYIKQVALITIMAQIGSYVPAEEATIGIVDGIFTRMSTFMEELTDTA
EIIRKATSQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTH
YPPVCELEKNYSHQVGNYHMGFLVSVTFLYQITRGIAARSYGLNVAKLAD
VPGEILKKAAHKSKELEGLINTKRKRLKYFAKLWTMHNAQDLQKWTEEFN
ME

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3thx Mechanism of mismatch recognition revealed by human MutSbeta bound to unpaired DNA loops
Resolution	2.7 Å
Binding residue (original residue number in PDB)	T221 P222 L223 C243 G244 Y245 H269 Q300 L316 F317 R319
Binding residue (residue number reindexed from 1)	T5 P6 L7 C27 G28 Y29 H53 Q84 L100 F101 R103
Binding affinity	PDBbind-CN: Kd=70pM

Enzyme Commision number

	Molecular Function
GO:0005524	ATP binding
GO:0030983	mismatched DNA binding
GO:0140664	ATP-dependent DNA damage sensor activity

	Biological Process
GO:0006298	mismatch repair

PDB	RCSB:3thx, PDBe:3thx, PDBj:3thx
PDBsum	3thx
PubMed	22179786
UniProt	P20585\|MSH3_HUMAN DNA mismatch repair protein Msh3 (Gene Name=MSH3)

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Structure of PDB 3thx Chain B Binding Site BS01