Structure of PDB 3sm4 Chain B Binding Site BS01

Receptor Information
>3sm4 Chain B (length=228) Species: 10710 (Lambdavirus lambda) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHMTPDIILQRTGIDVRAVEQGDDAWHKLRLGVITASEVHNVIAKPRSGK
KWPDMKMSYFHTLLAEVCTGVAPEVNAKALAWGKQYENDARTLFEFTSGV
NVTESPIIYRDESMRTACSPDGLCSDGNGLELACPFTSRDFMKFRLGGFE
AIKSAYMAQVQYSMWVTRKNAWYFANYDPRMKREGLHYVVIERDEKYMAS
FDEIVPEFIEKMDEALAEIGFVFGEQWR
Ligand information
Receptor-Ligand Complex Structure
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PDB3sm4 Crystal structures of {lambda} exonuclease in complex with DNA suggest an electrostatic ratchet mechanism for processivity.
Resolution1.88 Å
Binding residue
(original residue number in PDB)		R45 D52 M53 S56 N74 A75
Binding residue
(residue number reindexed from 1)		R47 D54 M55 S58 N76 A77
Enzymatic activity
Catalytic site (original residue number in PDB) E93 E102 D109 E129 L130 A131
Catalytic site (residue number reindexed from 1) E95 E104 D111 E131 L132 A133
Enzyme Commision number 3.1.11.3: exodeoxyribonuclease (lambda-induced).
Gene Ontology
Molecular Function
GO:0004527 exonuclease activity
GO:0046872 metal ion binding
GO:0051908 double-stranded DNA 5'-3' DNA exonuclease activity
Biological Process
GO:0006259 DNA metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3sm4, PDBe:3sm4, PDBj:3sm4
PDBsum3sm4
PubMed21730170
UniProtP03697|EXO_LAMBD Exonuclease (Gene Name=exo)

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