Structure of PDB 3slp Chain B Binding Site BS01

Receptor Information
>3slp Chain B (length=226) Species: 10710 (Lambdavirus lambda) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTPDIILQRTGIDVRAVEQGDDAWHKLRLGVITASEVHNVIAKPRSGKKW
PDMKMSYFHTLLAEVCTGVAPEVNAKALAWGKQYENDARTLFEFTSGVNV
TESPIIYRDESMRTACSPDGLCSDGNGLELKCPFTSRDFMKFRLGGFEAI
KSAYMAQVQYSMWVTRKNAWYFANYDPRMKREGLHYVVIERDEKYMASFD
EIVPEFIEKMDEALAEIGFVFGEQWR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3slp Crystal structures of {lambda} exonuclease in complex with DNA suggest an electrostatic ratchet mechanism for processivity.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		M53 S56 V73 A75
Binding residue
(residue number reindexed from 1)		M53 S56 V73 A75
Enzymatic activity
Catalytic site (original residue number in PDB) E93 E102 D109 E129 L130 K131
Catalytic site (residue number reindexed from 1) E93 E102 D109 E129 L130 K131
Enzyme Commision number 3.1.11.3: exodeoxyribonuclease (lambda-induced).
Gene Ontology
Molecular Function
GO:0004527 exonuclease activity
GO:0046872 metal ion binding
GO:0051908 double-stranded DNA 5'-3' DNA exonuclease activity
Biological Process
GO:0006259 DNA metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3slp, PDBe:3slp, PDBj:3slp
PDBsum3slp
PubMed21730170
UniProtP03697|EXO_LAMBD Exonuclease (Gene Name=exo)

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