Structure of PDB 3s3h Chain B Binding Site BS01

Receptor Information
>3s3h Chain B (length=285) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MASRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCN
RPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQG
PLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGD
IKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTL
VRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDI
FGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGK
Ligand information
Receptor-Ligand Complex Structure
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PDB3s3h Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D
Resolution2.8 Å
Binding residue
(original residue number in PDB)		F76 N78 A244 Q286
Binding residue
(residue number reindexed from 1)		F56 N58 A224 Q266
Enzymatic activity
Catalytic site (original residue number in PDB) D210 C242 R248 S249 Q286
Catalytic site (residue number reindexed from 1) D190 C222 R228 S229 Q266
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3s3h, PDBe:3s3h, PDBj:3s3h
PDBsum3s3h
PubMed22007620
UniProtP35992|PTP10_DROME Tyrosine-protein phosphatase 10D (Gene Name=Ptp10D)

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