Structure of PDB 3rw6 Chain B Binding Site BS01

Receptor Information
>3rw6 Chain B (length=244) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KNWFKITIPYGRKYDKAWLLSMIQSKCSVPFTPIEFHYENTRAQFFVEDA
STASALKAVNYKILDRENRRISIIINSSAPPHTILNELKPEQVEQLKLIM
SKRYDGSQQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRIIEENIPE
LLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLK
LEELWLDGNSLCDTFRDQSTYISAIRERFPKLLRLDGHELPPPI
Ligand information
>3rw6 Chain F (length=62) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggcacuaaccuaagacaggagggccgggaaaccugccuaauccaaugacg
gguaauaguguc
.<<<<<<<<<<......<<<<<<<.<<....>>.>>>>..>>>......>
>>>..>>>>>>.
Receptor-Ligand Complex Structure
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PDB3rw6 Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		T123 P125 Y126 E151 H153 Y154 N156 R158 Y177 N192 H198 R233 V246 N248 N275 R276 Y278 R279 K304 S305
Binding residue
(residue number reindexed from 1)		T7 P9 Y10 E35 H37 Y38 N40 R42 Y61 N76 H82 R117 V130 N132 N159 R160 Y162 R163 K188 S189
Binding affinityPDBbind-CN: Kd=0.09uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
Biological Process
GO:0006406 mRNA export from nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3rw6, PDBe:3rw6, PDBj:3rw6
PDBsum3rw6
PubMed21822283
UniProtQ9UBU9|NXF1_HUMAN Nuclear RNA export factor 1 (Gene Name=NXF1)

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