Structure of PDB 3q8s Chain B Binding Site BS01

Receptor Information
>3q8s Chain B (length=380) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVK
KLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFD
ENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVG
SQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESC
QHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIS
VAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLA
SLLNRVCQDGRKPHTVRLIIRRYSGRESRQCPIPSHVIQKLNYDVMTPMV
DILMKLFRNMVNVKMPFHLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3q8s Human DNA polymerase iota incorporating dTTP opposite 8-oxo-guanine
Resolution2.09 Å
Binding residue
(original residue number in PDB)		Q59 K60 E97 L99 R103 P299 Q300 S301 S303 E304 E305 S307
Binding residue
(residue number reindexed from 1)		Q33 K34 E71 L73 R77 P273 Q274 S275 S277 E278 E279 S281
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3q8s, PDBe:3q8s, PDBj:3q8s
PDBsum3q8s
PubMed
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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