Structure of PDB 3q8p Chain B Binding Site BS01

Receptor Information
>3q8p Chain B (length=380) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVK
KLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFD
ENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVG
SQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESC
QHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIS
VAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLA
SLLNRVCQDGRKPHTVRLIIRRYSGRESRQCPIPSHVIQKLNYDVMTPMV
DILMKLFRNMVNVKMPFHLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3q8p Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		Q59 K60 Y61 E97 L99 P299 Q300 S301 S303 E304 E305 S307 R347
Binding residue
(residue number reindexed from 1)		Q33 K34 Y35 E71 L73 P273 Q274 S275 S277 E278 E279 S281 R321
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3q8p, PDBe:3q8p, PDBj:3q8p
PDBsum3q8p
PubMed21300901
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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