Structure of PDB 3q7j Chain B Binding Site BS01

Receptor Information
>3q7j Chain B (length=780) Species: 273075 (Thermoplasma acidophilum DSM 1728) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEVEKYDLTLDFDIQKRTFNGTETITADAGDIVLDAVGLQINWMKVNGRD
TAFTYDGQTVRAPGDSQPQKIEISFAGKVSDSLSGIYYAGRENGMITTHF
QATDARRMFPCVDHPAYKAVFAITVVIDKDYDAISNMPPKRIEVSERKVV
EFQDTPRMSTYLLYVGIGKFRYEYEKYRDIDLILASLKDIRSKYPLDMAR
KSVEFYENYFGIPYALPKMHLISVPEFGAGAMENWGAITFREIYMDIAEN
SAVTVKRNSATVIAHEIAHQWFGDLVTMKWWNDLWLNESFATFMSYKTMD
TLFPEWSFWGDFFVSRTSGALRSDSLKNTHPIEVDVRDPDEISQIFDEIS
YGKGASILRMIEDYAGYEEFRKGISKYLNDHKFGNAEGSDLWTAIEDVSG
KPVKRVMEYWIKNPGYPVIKLKRNGRKITMYQTRFLLNGEEEGRWPVPVN
IKKKDGVERILLEDEASIEADGLIKINADSAGFYRVLYDDATFSDVMGHY
RDLSPLDRIGLVDDLFAFLLSGHIDPETYRQRIRNFFDDEDHNVITAIVG
QMEYLRMLTHAFDDDARAFCRSRMQFLTGKQDENLKIALGRVSRLYVMVD
ESYAEEMSKLFKDFDSAEPEMRSSIATAYALVTGDLKGLLEKFRSVDRDE
DRVRIISAFGKLKSNTDLSTVYGMVEKTEIKKQDMISFFSSALETLPGRE
FIFANLDRIIRLVIRYFTGNRTASRTVEMMIPVIGLDHPDAEDIVRNIGS
KNISMGLAKGIEMLAVNRKLVERIRQTAVK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3q7j Chain B Residue 800 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3q7j Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development
Resolution2.91 Å
Binding residue
(original residue number in PDB)		H265 H269 E288
Binding residue
(residue number reindexed from 1)		H265 H269 E288
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) E233 H265 E266 H269 E288 S343 Y351
Catalytic site (residue number reindexed from 1) E233 H265 E266 H269 E288 S343 Y351
Enzyme Commision number 3.4.11.-
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0043171 peptide catabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3q7j, PDBe:3q7j, PDBj:3q7j
PDBsum3q7j
PubMed21493078
UniProtO93655|TRF3_THEAC Tricorn protease-interacting factor F3 (Gene Name=trf3)

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