Structure of PDB 3q0a Chain B Binding Site BS01

Receptor Information

>3q0a Chain B (length=1094) Species: 10752 (Enquatrovirus N4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TEELKEGIDAVYPSLVGTADSKAEGIKNYFKLSFTLPEEQKSRTVGSEAP
LKDVAQALSSRARYELFTEKETANPAFNGEVIKRYKELMEHGEGIADILR
SRLAKFLNTKDVGKRFAQGTEANRWVGGKLLNIVEQDGDTFKYNEQLLQT
AVLAGLQWRLTATSNTAIKDAKDVAAITGIDQALLPEGLVEQFDTGMTLT
EAVSSLAQKIESYWGLSRNPNAPLGYTKGIPTAMAAEILAAFVESTDVVE
NIVDMSEIDPDNKKTIGLYTITELDSFDPINSFPTAIEEAVLVNPTEKMF
FGDDIPPVANTQLRNPAVRNTPEQKAALKAEQATEFYVHTPMVQFYETLG
KDRILELMGAGTLNKELLNDNHAKSLEGKNRSVEDSYNQLFSVIEQVRAQ
SEDISTVPIHYAYNMTRVGRMQMLGKYNPQSAKLVREAILPTKATLDLSN
QNNEDFSAFQLGLAQALDIKVHTMTREVMSDELTKLLEGNLKPAIDMMVE
FNTTGSLPENAVDVLNTALGDRKSFVALMALMEYSRYLVAEDKSAFVTPL
YVEADGVTNGPINAMMLMTGGLFTPDWIRNIAKGGLFIGSPNKTMNEHRS
TADNNDLYQASTNALMESLGKLRSNYASNMPIQSQIDSLLSLMDLFLPDI
NLGENGALELKRGIAKNPLTITIYGSGARGIAGKLVSSVTDAIYERMSDV
LKARAKDPNISAAMAMFGKQAASEAHAEELLARFLKDMETLTSTVPVKRK
GVLELQSTGTGAKGKINPKTYTIKGEQLKALQENMLHFFVEPLRNGITQT
VGESLVYSTEQLQKATQIQSVVLEDMFKQRVQEKLAEKAKDPTWKKGDFL
TQKELNDIQASLNNLAPMIETGSQTFYIAGSENAEVANQVLATNLDDRMR
VPMSIYAPAQAGVAGIPFMTIGTGDGMMMQTLSTMKGAPKNTLKIFDGMN
IGLNDITDASRKANEAVYTSWQGNPIKNVYESYAKFMKNVDFSKLSPEAL
EAIGKSALEYDQRENATVDDIANAASLIERNLRNIALGVDIRHKVLDKVN
LSIDQMAAVGAPYQNNGKIDLSNMTPEQQADELNKLFREELEAR

Ligand information

>3q0a Chain D (length=20) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gtcaaaagaagcggagcttc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3q0a X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides.
Resolution	2.69 Å
Binding residue (original residue number in PDB)	K114 R119 W129 K173 K176 D177 I181 T202 T204 E205 K267 K268 T269 G271 R318 R421 I675 Y678 S680 G681 K849 K850 A888 D901 R902 R904 G916 V917 P921
Binding residue (residue number reindexed from 1)	K110 R115 W125 K169 K172 D173 I177 T198 T200 E201 K263 K264 T265 G267 R314 R417 I671 Y674 S676 G677 K845 K846 A884 D897 R898 R900 G912 V913 P917

Enzymatic activity

Enzyme Commision number

2.7.7.6: DNA-directed RNA polymerase.

External links

PDB	RCSB:3q0a, PDBe:3q0a, PDBj:3q0a
PDBsum	3q0a
PubMed	21321236
UniProt	Q859P9\|RPOLV_BPN4 Virion DNA-directed RNA polymerase (Gene Name=50)

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