Structure of PDB 3pzp Chain B Binding Site BS01

Receptor Information
>3pzp Chain B (length=443) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMM
QQKAQITSQQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMR
DNPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVP
PNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDK
RRYFIKNSVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSD
KNKPNGQYQILPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTE
LYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEI
NKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVS
SVVSTAEEIFAIAKELLKTEIDADFPHPLRLRLMGVRISSFPN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3pzp Role of human DNA polymerase kappa in extension opposite from a cis-syn thymine dimer.
Resolution3.336 Å
Binding residue
(original residue number in PDB)		E199 G356 G358 T361 R454 K468 T469 R470 A471 T473
Binding residue
(residue number reindexed from 1)		E181 G281 G283 T286 R379 K393 T394 R395 A396 T398
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3pzp, PDBe:3pzp, PDBj:3pzp
PDBsum3pzp
PubMed21354175
UniProtQ9UBT6|POLK_HUMAN DNA polymerase kappa (Gene Name=POLK)

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